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TXNIP regulates per...
TXNIP regulates peripheral glucose metabolism in humans
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- Parikh, Hemang (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Nilsson, Emma A (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Chutkow, William A. (author)
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- Johansson, Lovisa (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Storgaard, Heidi (author)
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Poulsen, Pernille (author)
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Saxena, Richa (author)
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Ladd, Christine (author)
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Schulze, P. Christian (author)
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Mazzini, Michael J. (author)
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Jensen, Christine Bjorn (author)
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- Krook, Anna (author)
- Karolinska Institutet
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- Bjornholm, Marie (author)
- Karolinska Institutet
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Tornqvist, Hans (author)
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- Zierath, Juleen R. (author)
- Karolinska Institutet
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- Ridderstråle, Martin (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Altshuler, David (author)
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Lee, Richard T. (author)
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Vaag, Allan (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Mootha, Vamsi K. (author)
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Carlsson, E (author)
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(creator_code:org_t)
- 2007-05-01
- 2007
- English.
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In: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1676. ; 4:5, s. 868-879
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Abstract
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- Background Type 2 diabetes mellitus ( T2DM) is characterized by defects in insulin secretion and action. Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure. Methods and Findings We combined human insulin/glucose clamp physiological studies with genome-wide expression profiling to identify thioredoxin interacting protein ( TXNIP) as a gene whose expression is powerfully suppressed by insulin yet stimulated by glucose. In healthy individuals, its expression was inversely correlated to total body measures of glucose uptake. Forced expression of TXNIP in cultured adipocytes significantly reduced glucose uptake, while silencing with RNA interference in adipocytes and in skeletal muscle enhanced glucose uptake, confirming that the gene product is also a regulator of glucose uptake. TXNIP expression is consistently elevated in the muscle of prediabetics and diabetics, although in a panel of 4,450 Scandinavian individuals, we found no evidence for association between common genetic variation in the TXNIP gene and T2DM. Conclusions TXNIP regulates both insulin-dependent and insulin- independent pathways of glucose uptake in human skeletal muscle. Combined with recent studies that have implicated TXNIP in pancreatic beta-cell glucose toxicity, our data suggest that TXNIP might play a key role in defective glucose homeostasis preceding overt T2DM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Parikh, Hemang
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Nilsson, Emma A
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Chutkow, William ...
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Johansson, Lovis ...
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Storgaard, Heidi
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Poulsen, Pernill ...
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show more...
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Saxena, Richa
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Ladd, Christine
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Schulze, P. Chri ...
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Mazzini, Michael ...
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Jensen, Christin ...
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Krook, Anna
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Bjornholm, Marie
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Tornqvist, Hans
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Zierath, Juleen ...
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Ridderstråle, Ma ...
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Altshuler, David
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Lee, Richard T.
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Vaag, Allan
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Groop, Leif
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Mootha, Vamsi K.
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Carlsson, E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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PLoS Medicine
- By the university
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Lund University
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Karolinska Institutet